Caveolae and neurotrophins in pulmonary artery smooth muscle
نویسندگان
چکیده
منابع مشابه
Heterogeneous activation of p19 in pulmonary artery smooth muscle cells
Solodushko V, Alvarez DF, Viator R, Messerall T, Fouty B. Heterogeneous activation of p19 in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 300: L642–L647, 2011. First published January 7, 2011; doi:10.1152/ajplung.00117.2010.— p19 is a tumor suppressor that leads to cell cycle arrest or apoptosis by stabilizing p53. p19 is not critical for cell cycle regulation under ...
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Pulmonary vasoconstriction and vascular medial hypertrophy greatly contribute to the elevated pulmonary vascular resistance in patients with pulmonary hypertension. A rise in cytosolic free Ca(2+) ([Ca(2+)](cyt)) in pulmonary artery smooth muscle cells (PASMC) triggers vasoconstriction and stimulates cell growth. Membrane potential (E(m)) regulates [Ca(2+)](cyt) by governing Ca(2+) influx throu...
متن کاملHeterogeneous activation of p19Arf in pulmonary artery smooth muscle cells.
p19(ARF) is a tumor suppressor that leads to cell cycle arrest or apoptosis by stabilizing p53. p19(ARF) is not critical for cell cycle regulation under normal conditions, but loss of p19(ARF) is seen in many human cancers, and a murine p19(Arf) knockout model leads to malignant proliferation and tumor formation; its role in controlling nonmalignant proliferation is less defined. To examine thi...
متن کاملCaveolae intracellulares and sarcoplasmic reticulum in smooth muscle.
In the last 15 years several electron-microscope studies of visceral and vascular smooth muscle of vertebrates have been published (see reviews by Dewey & Barr, 1968, and Burnstock, 1970). The presence of bottle-shaped invaginations of the sarcolemmal membrane (micropinocvtotic vesicles, caveolae intracellulares) (Caesar, Edwards & Ruska, 1957) is well known. However, it is generally accepted t...
متن کاملCaveolae and propofol effects on airway smooth muscle.
BACKGROUND The i.v. anaesthetic propofol produces bronchodilatation. Airway relaxation involves reduced intracellular Ca(2+) ([Ca(2+)](i)) in airway smooth muscle (ASM) and lipid rafts (caveolae), and constitutional caveolin proteins regulate [Ca(2+)](i). We postulated that propofol-induced bronchodilatation involves caveolar disruption. METHODS Caveolar fractions of human ASM cells were test...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.769.6